Gametophyte Development Needs Mitochondrial Coproporphyrinogen III Oxidase Function
نویسندگان
چکیده
منابع مشابه
Hexachlorobenzene treatment on hepatic mitochondrial function parameters and intracellular coproporphyrinogen oxidase location.
These studies try to elucidate why isocoproporphyrin appears in hexachlorobenzene-poisoned rats' feces. Chronic exposure of hexachlorobenzene to rats produces an experimental model for human porphyria cutanea tarda. After 8 weeks of treatment, rats showed high porphyrin excreta and 50% inhibition of liver uroporphyrinogen decarboxylase activity. Uroporphyrin plus heptacarboxylic porphyrin excee...
متن کاملMale Gametophyte Development and Function
Male gametophyte development in higher plants is a complex process that requires the coordinated participation of various cell and tissue types and their associated specific gene expression patterns. The male gametophytic life cycle can be divided into a developmental phase leading to the formation of mature pollen grains, and a functional or progamic phase, beginning with the impact of the gra...
متن کاملAntibacterial photosensitization through activation of coproporphyrinogen oxidase.
Gram-positive bacteria cause the majority of skin and soft tissue infections (SSTIs), resulting in the most common reason for clinic visits in the United States. Recently, it was discovered that Gram-positive pathogens use a unique heme biosynthesis pathway, which implicates this pathway as a target for development of antibacterial therapies. We report here the identification of a small-molecul...
متن کاملOxygen-dependent coproporphyrinogen-III oxidase from Escherichia coli: one-step purification and biochemical characterisation.
Coproporphyrinogen-III oxidase (CPO) catalyses the conversion of coproporphyrinogen-III to protoporphyrinogen-IX in the haem biosynthetic pathway, and its deficient activity is associated with human hereditary coproporphyria. The 47% sequence identity between the oxygen-dependent CPO from Escherichia coli and its human counterpart makes the bacterial enzyme a good model system for structural st...
متن کاملCrystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes.
'Radical SAM' enzymes generate catalytic radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. We present the first crystal structure of a Radical SAM enzyme, that of HemN, the Escherichia coli oxygen-independent coproporphyrinogen III oxidase, at 2.07 A resolution. HemN catalyzes the essential conversion of coproporphyrinogen III to protoporphyrinogen IX dur...
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ژورنال
عنوان ژورنال: Plant Physiology
سال: 2017
ISSN: 0032-0889,1532-2548
DOI: 10.1104/pp.16.01482